Publications and Presentations
1. Braell, W.A., Tyo, M.A.,
Krag, S.S., and Robbins, P.W. "A New Procedure for
the
Preparation of GDP-[U-14C]Mannose." Analytical Biochemistry 74, pp.
484-487
(1976).
2. Tyo, M. A. and Wang, D.I.C. "A Characterization of
Engineering Parameters of
Cell
and Virus Production Using Controlled-Charge Microcarriers."
Presented
at the 1979 Annual Meeting of the American Chemical Society,
Washington,
D. C., September, 1979.
3. Tyo, M.A., and Wang, D.I.C. "Engineering
Characterization of Animal Cell and
Virus
Production Using Controlled-Charge Microcarriers." in "Advances in
Biotechnology
Vol. I: Scientific and Engineering Principles", M. Moo-
Young,
C. W. Robinson, and C. Vezina, eds. Pergamon Press. pp. 141-146
(1980).
4. Sinskey, A.J., Fleischaker, R.J., Tyo, M.A., Giard D.J.,
and Wang, D.I.C.
"Production
of Cell Derived Products: Virus and Interferon." Annals of
the
New York Academy of Science 369, pp. 47-59 (1981).
5. D'Amico, D.J., Dryja, T.P., Tyo, M.A., Craft, J.L., and
Albert, D.M. "Mass
Culture
of Bovine Ocular Cells Using Microcarriers." Investigative
Ophthalmology
and Visual Science 20(3 Suppl.), p. 79 (1981).
6. D'Amico, D.J., Dryja, T.P., Tyo, M.A., Craft, J.L., and
Albert, D.M. "Mass
Cultivation
of Bovine Ocular Pigment Epithelia in Microcarrier Suspension
Culture."
Investigative Ophthalmology and Visual Science 23(3), pp. 332-
339
(1982).
7. Tyo, M.A. and Hu, W-S. "Mass Transfer in Hollow Fiber
Cell Culture."
Presented
at 1986 Annual Meeting of the Society for Industrial
Microbiology,
San Francisco, CA, August, 1986.
8. Tyo, M.A. and Hu, W-S. "Hollow Fiber Cell Culture:
Effect of Flow Patterns."
Presented
at the 1986 Annual Meeting of the American Chemical Society,
Anaheim,
CA, September, 1986.
9. Tyo, M.A. and Spier, R.E. "Dense Cultures of Animal
Cells at the Industrial
Scale."
Enzyme and Microbial Technology 9, pp. 514-520 (1987).
10. Tyo, M.A., Zaspel, B., and
Murphy, T. "Large-Scale Mammalian Cell Culture
Utilizing
ACUSYST Technology." in "Animal Cell Biotechnology Vol. 3",
R.E.
Spier and J.B. Griffiths, eds. Academic Press, N.Y. pp. 357-371
(1988).
11. Oller. A.R,, Buser, C.W.,
Tyo, M.A., and Thilly, W.G. "Growth of Mammalian
Cells
at High Oxygen Concentrations." Journal of Cell Science 94, pp. 43-
49
(1989).
12. Tyo, M.A. and Thilly, W.G.
"Novel High Density Perfusion System For
Suspension
Culture Metabolic Studies." Presented at the 1989 Annual
Meeting
of the American Institute of Chemical Engineers, San Francisco,
CA,
November, 1989.
13. Tyo, M.A. “Evaluating
Scalability of Cell Culture Technologies: Factors
Involved
with Selecting Early-Stage Bioreactor Designs.” Presented at IBC’s
Conference
on Transitions from Bench to Clinic: Early Stage Production and
Purification
Development for Biologics, San Francisco, CA, August 2000.
14. Tyo, M.A. “The Development of Microencapsulated DNA for Targeted Delivery
of Therapeutic Vaccines.” Presented at IBC’s Formulation Strategies for
Biopharmaceuticals,
San Diego, CA, March 2001.
15. Tyo, M.A. "Capacity
Planning for Late Stage Development and Commercial
Launch."
Presented at the 2007 Meeting of the BioProcess International
Conference
and Exhibition. Boston, MA,
October 2007.
16. Tyo, M.A. “Building a Strategic manufacturing Alliance: A
Risky Business.”
Presented at the 2009 BIO International Convention. Atlanta, GA, May 2009.
